Hypersensitivity to cephalosporins and penicillin.
The first trimester of pregnancy. Be wary – sustanon 300 in newborns, premature babies, kidney / liver failure, ulcerative colitis, enteritis or colitis associated with the use of antibacterial drugs, pregnancy, lactation.
Dosage and administration:
For adults and children over 12 years:
The average daily dose is 1-2 g of ceftriaxone 1 per day (24 hours).
In severe cases, or in cases of infections caused by moderately susceptible pathogens, disposable daily dose may be increased to 4 g . : For newborns, infants and children up to 12 years : The following scheme is recommended for single daily dose for infants (up to two weeks of age): 20-50 mg / kg of body weight per day (a dose of 50 mg / kg body weight must not be exceeded in due to immature neonates enzyme system). for infants and children up to 12 years: daily dose is 20-75 mg / kg body weight. In children with a body weight of 50 kg or more should follow the dosage for adults. The dose of 50 mg / kg of body weight should be administered by intravenous infusion for at least 30 minutes. Duration of therapy: depends on the disease. Combination therapy: The experiments proved that between ceftriaxone and aminoglycosides in their effect on many Gram-negative bacteria there is a synergy. . Although predict potentiated effect of such combinations can not, in cases of severe and life-threatening infections (eg, caused by Pseudomonas aeruginosa) justified their co-administration in connection with the physical incompatibility of ceftriaxone and aminoglycosides need to assign them to the recommended doses apart! Meningitis: In bacterial meningitis infants and children the initial dose of 100 mg / kg of body weight once per day (maximum 4 g). Once the pathogen to allocate and to determine its sensitivity dose should be sustanon 300 reduced accordingly. The best results were achieved with the following timing of therapy.
For the treatment of gonorrhea caused by both generators and neobrazuyuschimi penicillinase strains, the recommended dose is 250 mg intramuscularly. Prevention in the pre- and postoperative period:Before infected or suspected infected surgical interventions for the prevention of postoperative infections, depending on the risk of infection, 30-90 minutes prior to surgery is recommended single injection of ceftriaxone in a dose of 1-2 g Insufficient renal and hepatic function: in patients with impaired renal function, under normal liver function, reduce the dose of ceftriaxone is not necessary. Only with renal insufficiency in preterminal stage (creatinine clearance below 10 ml / min), it is necessary that the daily dose of ceftriaxone should not exceed 2 g. In patients with impaired liver function, while maintaining renal function, ceftriaxone dose is reduced as it is not necessary. In the case of simultaneous the presence of severe liver disease and kidney failure in the serum concentration of ceftriaxone should be regularly monitored. In patients undergoing hemodialysis, the dose after this procedure, there is no need to change. Intramuscular: recommended to enter no more than 1 to intramuscular injection of 1 g of the drug should be diluted in 3.5 mL of 1% lidocaine and enter deeply into the gluteal muscle, g in one buttock. Lidocaine solution should never be administered intravenously! Intravenous administration: For intravenous injection of 1 g of the drug must dissolve in 10 ml of sterile distilled water and administered by slow intravenous injection over 2-4 minutes. Intravenous infusion: . The duration of an intravenous infusion for at least 30 minutes for sustanon 300 intravenous infusion 2 g of the powder should be diluted with approximately 40 ml of calcium-free solution, for example: 0.9% sodium chloride solution, 5% glucose solution, a 10% glucose solution, a 5% solution levulose.