sustanon 250 cycle

The pharmacokinetics of sustanon 250 cycle ustekinumab in children aged 12 to 18 years, c psoriasis receiving the recommended dose is comparable to the pharmacokinetics in adult patients with psoriasis.
Pharmacokinetics studies in elderly patients have been conducted.
The population pharmacokinetic analysis in patients over 65 years of age showed no effect on the magnitude of the apparent clearanceand volume of distribution .

Patients with impaired renal function
data on the pharmacokinetics of the drug in patients with impaired renal function are not available.

Patients with impaired liver function
data on the pharmacokinetics of the drug in patients with impaired liver function no.

Other groups of patients
The pharmacokinetics of ustekinumab comparable in Asian patients with psoriasis and in patients with non-Asian psoriasis. The use of alcohol or tobacco did not affect the pharmacokinetics of ustekinumab.

testimony

plaque psoriasis

Adult patients
Treatment of patients over 18 years of age with moderate to severe plaque psoriasis in the absence of the effect of the treatment or in the presence of contraindications or intolerance to other methods for systemic sustanon 250 cycle therapy or phototherapy.

Children
Treatment of children aged 12 to 18 years with moderate to severe plaque psoriasis in the absence of the effect of the treatment or in the presence of contraindications or intolerance to other methods for systemic therapy or phototherapy.

Psoriatic arthritis
Treatment of patients over 18 years of age with active psoriatic arthritis (PsA) as monotherapy or in combination with methotrexate.

Contraindications

– Clinically significant hypersensitivity to ustekinumab or any excipient product;
– Children under the age of 12 years (as indicated by “plaque psoriasis”), up to 18 years (as indicated by “psoriatic arthritis”);
– Pregnancy and lactation;
– Serious infectious disease acute phase, including tuberculosis;
– Malignant neoplasm.

Carefully

– Chronic or recurrent parasitic and infectious diseases of viral, fungal or bacterial origin.
– Malignant tumors in anamnesis.
– Older age.

Use during pregnancy and lactation

Pregnancy
During the study drug was administered to animals in a dose of 45 times the recommended clinical dose for humans, while there was no evidence of teratogenicity effects, birth defects or developmental delays. However, the results from animal studies are not always applicable to humans.
It is unknown whether ustekinumab is when used in pregnant women result in adverse effects on the fetus or affect reproductive function. There are no adequate and well-controlled studies in pregnant women have been conducted.
It is not recommended sustanon 250 cycle to use the drug during pregnancy, effective methods of contraception during and for 15 weeks after treatment with the drug should be used.

Lactation
Studies in monkeys showed that ustekinumab is excreted in breast milk. It is not known whether the drug is absorbed systemically after absorption. Because many drugs and immunoglobulins are excreted in human milk and because the drug Ctelara ® can cause adverse reactions in infants, should decide to breast-feed while taking this drug, or the abolition of ustekinumab therapy.

Dosing and Administration

Preparation Ctelara ® is intended for subcutaneous injection.

Adult patients

Plaque psoriasis
The recommended dose is 45 mg. Making a second injection 4 weeks after the first application, then every 12 weeks. In patients weighing more than 100 kg of the drug is recommended at a dose of 90 mg.
In case of failure of therapy for 28 weeks is recommended to consider the appropriateness of the drug.

Dose adjustment
Patients who have clinical efficacy in the application every 12 weeks expressed enough, increase the dose to 90 mg every 12 weeks. In such case the dosing regimen is not effective, the dose should be administered 90 mg every 8 weeks.

The resumption of treatment
was shown, that the resumption of therapy according to the scheme: a second injection 4 weeks after the first application, and then every 12 weeks, is effective and safe.

Psoriatic arthritis
The recommended dose is 45 mg. Making sustanon 250 cycle a second injection 4 weeks after the first application, then every 12 weeks. In patients weighing more than 100 kg of the drug it is recommended to use a dose of 90 mg. anazole

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