sustanon 250 reviews

The critical cations solution composition similar to the composition of the blood plasma. In connection with this solution is used to correct fluid and electrolyte abnormalities. When using electrolyte solutions osmotic balance is restored and / or maintained, both inside and outside the cells. Malate sustanon 250 reviews is oxidized and has a mild alkaline effect. The solution contains 5% glucose. At a dose level of 40 ml / kg body weight per day administered glucose amount sufficient to cover the needs of the organism of 2 g / kg body weight per day (gipokaloricheskaya infusion therapy).

Indications

 

  • isotonic dehydration;
  • hypotonic dehydration;
  • replacement of extracellular volume of isotonic solution with partial coverage of energy needs of the organism;
  • dilution of concentrated electrolyte solutions and medicines.Contraindications :
  • hyperhydration;
  • hypertonic dehydration;
  • hypokalemia;
  • hypernatremia,
  • hyperchloremia;
  • diseases in which should limit sodium intake, such as heart failure; edema, pulmonary edema, hypertension, eclampsia, severe renal insufficiency;
  • persistent hyperglycemia, do not respond to insulin in a dose of up to 6 units / hour.Pregnancy and lactation
    drug can be used during pregnancy and lactation, but should be used with caution in women with eclampsia.

    Dosing and Administration Dose Dose selected individually according to the patient’s needs and the liquid electrolyte. The maximum daily dose: Up to 40 ml per kg body weight per day, respectively, 2.0 g of glucose per kg of body weight per day. The administration rate: up to 5 ml / kg body weight / hour (1.7 drops / min kg), respectively 0.25 g of glucose per kg of body weight / hour. for patients with a body weight of 70 kg the maximum delivery rate of 350 ml / hr or 120 drops / min. This corresponds to 17.5 g / h of glucose. Duration of solution may be used for several days. Duration of use is determined by the clinical condition of a patient, and laboratory parameters.

  • Method of application: For sustanon 250 reviews intravenous administration. General recommendations for the use of carbohydrates: In the normal metabolism of the total amount of carbohydrates administered should not exceed 350 to 400 grams per day. The introduction of such doses of glucose is completely oxidized. Assigning higher doses may account for the appearance of side effects such as fatty liver disease. In conditions of impaired metabolism, for example after major surgery or injury or hypoxic stress organ failure daily dosage should be reduced to 200-300 g, which corresponds to 3 g / kg body weight per day. Selection of individual doses includes mandatory laboratory monitoring. The following restrictions must be strictly observed dose for adults: 0.25 g of glucose per kg of body weight per hour and up to 6 g per kg of body weight per day. When assigning solutions containing carbohydrates (regardless of concentration) must always monitor the concentration of glucose in the blood as the surgical intervention and the patient under conservative management. To prevent overdosing recommended carbohydrate infusion pumps, especially when using solutions with a high concentration of carbohydrate.
  • General instructions for the application of fluid and electrolyte solutions: Level of 30 ml per kg body weight per day of the body covers only physiological fluid needs. In patients undergoing surgery, patients resuscitated and fluid sustanon 250 reviews requirements increase due to the concentration of reduced renal function and increased excretion of metabolic products, which leads to the need to increase fluid intake to about 40 ml / kg body weight per day. Additional losses (fever, diarrhea, fistula, vomiting, etc.) necessary to compensate for an even higher by introducing the liquid whose level is determined individually. Actual individual fluid level needs defined sequential monitoring clinical and laboratory parameters (urine, serum, and urine osmolality, determination allocated substances). The main substitution of sodium and potassium cations major reaches 1.5-3 mmol per kg / body weight per day and 0 , 8-1,0 mmol per kilogram body weight per day, respectively. Actual requirements during infusion therapy defined electrolyte balance and monitoring of plasma concentrations of electrolytes.

     

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sustanon 250

Allergic reactions sustanon 250: urticaria, chills or fever, rash, pruritus, rarely – bronchospasm, eosinophilia, Stevens-Johnson syndrome, erythema polymorphous exudative, serum sickness, angioedema, anaphylactic shock. With storota digestive system: nausea, vomiting, diarrhea, or constipation, flatulence, abdominal pain, taste disturbance, stomatitis, glossitis, pseudomembranous enterocolitis, liver dysfunction (increased activity of “liver” transaminases, less often – ALP or bilirubin, cholestatic jaundice), dysbiosis. From the side of hematopoiesis: leukopenia, neutropenia, granulocytopenia , lymphopenia, thrombocytosis, thrombocytopenia, hemolytic anemia, anticoagulation, lowering of plasma coagulation factors , prolonged prothrombin time. From the urinary system: renal dysfunction (azotemia, increased urea in the blood, hypercreatininemia , glucosuria, cylindruria, hematuria), oliguria, anuria. Local reactions: phlebitis, pain along the vein, pain and infiltration in the ground / m introduction. Other: headache, dizziness, nosebleeds, candidiasis, superinfection.

Drug Interactions
Ceftriaxone and aminoglycosides have synergistic against many gram-negative bacteria.
Incompatible with ethanol.
NSAIDs, and others. Platelet aggregation inhibitors increase the chance of bleeding.
In an application with the “loop” diuretics, etc. The risk of increased nephrotoxic drugs nephrotic effect.
Pharmaceutical incompatible sustanon 250 with solutions containing other. antibiotics.
You can not mix in the same infusion vial or a syringe with other antibiotic (chemical incompatibility).

 

Overdose:

Excessively high concentrations of ceftriaxone in plasma can not be reduced by hemodialysis or peritoneal dialysis. For treatment of overdose symptomatic measures are recommended.

 

Special instructions:

Ceftriaxone is used only in a hospital.
When simultaneous severe renal and hepatic impairment should be regular monitoring of the concentration of drug in plasma.
In patients on hemodialysis, you must monitor the concentration of ceftriaxone in plasma, because have its elimination rate may be reduced.
In the long-term treatment should regularly monitor the picture of peripheral blood indicators of the functional state of the liver and kidneys.
On rare occasions, ultrasound gallbladder sustanon 250 marked darkening, which disappear after the cancellation (even if this phenomenon is accompanied by pain in the right hypochondria, recommends continuation of the appointment of an antibiotic and conduct symptomatic treatment).
During treatment contraindicated use of ethanol – can disulfiramipodobnye effects (facial flushing, abdominal cramps and in the stomach, nausea, vomiting, headache, decreased blood pressure, tachycardia, shortness of breath).
in spite of the detailed medical history, that is the rule for other cephalosporin antibiotics, can not exclude the possibility of an anaphylactic shock, which require immediate treatment – first intravenous adrenaline, then glucocorticoids.
Studies in vitro have shown that, like other cephalosporin antibiotics ceftriaxone is able to displace bilirubin bound to albumin serum. Therefore, in infants with hyperbilirubinemia and especially in premature infants, the use of ceftriaxone requires even more care.
With long-term use requires periodic monitoring of blood formula. Freshly prepared solutions of ceftriaxone is physically and chemically stable for 6 hours at room temperature.
In the appointment during lactation should be abolished breastfeeding.
Elderly or debilitated patients may require vitamin C.

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sustanon 300

Hypersensitivity to cephalosporins and penicillin.
The first trimester of pregnancy. Be wary – sustanon 300 in newborns, premature babies, kidney / liver failure, ulcerative colitis, enteritis or colitis associated with the use of antibacterial drugs, pregnancy, lactation.

 

Dosage and administration:

For adults and children over 12 years:
The average daily dose is 1-2 g of ceftriaxone 1 per day (24 hours).
In severe cases, or in cases of infections caused by moderately susceptible pathogens, disposable daily dose may be increased to 4 g . : For newborns, infants and children up to 12 years : The following scheme is recommended for single daily dose for infants (up to two weeks of age): 20-50 mg / kg of body weight per day (a dose of 50 mg / kg body weight must not be exceeded in due to immature neonates enzyme system). for infants and children up to 12 years: daily dose is 20-75 mg / kg body weight. In children with a body weight of 50 kg or more should follow the dosage for adults. The dose of 50 mg / kg of body weight should be administered by intravenous infusion for at least 30 minutes. Duration of therapy: depends on the disease. Combination therapy: The experiments proved that between ceftriaxone and aminoglycosides in their effect on many Gram-negative bacteria there is a synergy. . Although predict potentiated effect of such combinations can not, in cases of severe and life-threatening infections (eg, caused by Pseudomonas aeruginosa) justified their co-administration in connection with the physical incompatibility of ceftriaxone and aminoglycosides need to assign them to the recommended doses apart! Meningitis: In bacterial meningitis infants and children the initial dose of 100 mg / kg of body weight once per day (maximum 4 g). Once the pathogen to allocate and to determine its sensitivity dose should be sustanon 300 reduced accordingly. The best results were achieved with the following timing of therapy.
Gonorrhea:
For the treatment of gonorrhea caused by both generators and neobrazuyuschimi penicillinase strains, the recommended dose is 250 mg intramuscularly. Prevention in the pre- and postoperative period:Before infected or suspected infected surgical interventions for the prevention of postoperative infections, depending on the risk of infection, 30-90 minutes prior to surgery is recommended single injection of ceftriaxone in a dose of 1-2 g Insufficient renal and hepatic function: in patients with impaired renal function, under normal liver function, reduce the dose of ceftriaxone is not necessary. Only with renal insufficiency in preterminal stage (creatinine clearance below 10 ml / min), it is necessary that the daily dose of ceftriaxone should not exceed 2 g. In patients with impaired liver function, while maintaining renal function, ceftriaxone dose is reduced as it is not necessary. In the case of simultaneous the presence of severe liver disease and kidney failure in the serum concentration of ceftriaxone should be regularly monitored. In patients undergoing hemodialysis, the dose after this procedure, there is no need to change. Intramuscular: recommended to enter no more than 1 to intramuscular injection of 1 g of the drug should be diluted in 3.5 mL of 1% lidocaine and enter deeply into the gluteal muscle, g in one buttock. Lidocaine solution should never be administered intravenously! Intravenous administration: For intravenous injection of 1 g of the drug must dissolve in 10 ml of sterile distilled water and administered by slow intravenous injection over 2-4 minutes. Intravenous infusion: . The duration of an intravenous infusion for at least 30 minutes for sustanon 300 intravenous infusion 2 g of the powder should be diluted with approximately 40 ml of calcium-free solution, for example: 0.9% sodium chloride solution, 5% glucose solution, a 10% glucose solution, a 5% solution levulose. Read more about Trenbolone effects

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sustanon 250 for sale

For parenteral administration of ceftriaxone well penetrates the tissues and body fluids.
In healthy adult subjects for ceftriaxone is characterized by long, about 8 hours, the half-life. The areas under the curve concentration – time in blood serum after intravenous and intramuscular administration of the same. This sustanon 250 for sale means that the bioavailability of ceftriaxone administered intramuscularly is 100%. When intravenous ceftriaxone diffuses quickly into the interstitial fluid, where its bactericidal activity against pathogens sensitive to it retains for 24 hours.
The half-life in healthy adult subjects is about 8 hours. Newborn to 8 days and the elderly over 75 years, the average half-life of approximately twice. In adults, 50-60% of ceftriaxone is excreted unchanged form in the urine, and 40-50% – in unchanged form with bile. Under the influence of the intestinal flora ceftriaxone converted into an inactive metabolite. In newborns about 70% of the administered dose excreted by the kidneys. When kidney failure or liver disease in adults pharmacokinetics of ceftriaxone is almost unchanged, elimination half-life is lengthened slightly. If renal function is impaired, increased excretion in the bile, and if there is a liver pathology, the enhanced release of ceftriaxone kidneys.
Ceftriaxone is reversibly bound to sustanon 250 for sale albumin, and this binding is inversely proportional to the concentration of, for example, at a concentration in the blood serum of the drug is less than 100 mg / L binding ceftriaxone protein is 95%, and at a concentration of 300 mg / l – 85% only. Due to the lower content of albumin in the interstitial fluid ceftriaxone concentration in it is higher than in the serum. Penetration into the cerebrospinal fluid: In infants and children with inflammation of the meninges ceftriaxone penetrates into the cerebrospinal fluid, while in the case of bacterial meningitis, an average of 17% concentration in serum drug diffuses in the cerebrospinal fluid, which is about 4 times greater than in aseptic meningitis. 24 hours after intravenous administration of ceftriaxone 50-100 mg / kg body weight concentration in the cerebrospinal fluid higher than 1.4 mg / l. In adult patients with meningitis over 2-25 hours after administration of ceftriaxone 50 mg / kg body weight several times higher than the concentration of ceftriaxone depressing the minimum dose required to inhibit the pathogens most frequently causing meningitis.

 

Indications for use:

Infections caused by sensitive sustanon 250 for sale to ceftriaxone pathogens:
sepsis, meningitis, abdominal infections (peritonitis, inflammatory diseases of the gastrointestinal tract, biliary tract) infections of bones, joints, connective tissue, skin, infection in patients with reduced function of the immune system, kidney infection and urinary tract infections, respiratory tract infections, particularly pneumonia, and upper respiratory tract infections, genital infections, including gonorrhea.
Prevention of infection in the postoperative period.

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sustanon 250 cycle

The pharmacokinetics of sustanon 250 cycle ustekinumab in children aged 12 to 18 years, c psoriasis receiving the recommended dose is comparable to the pharmacokinetics in adult patients with psoriasis.
Pharmacokinetics studies in elderly patients have been conducted.
The population pharmacokinetic analysis in patients over 65 years of age showed no effect on the magnitude of the apparent clearanceand volume of distribution .

Patients with impaired renal function
data on the pharmacokinetics of the drug in patients with impaired renal function are not available.

Patients with impaired liver function
data on the pharmacokinetics of the drug in patients with impaired liver function no.

Other groups of patients
The pharmacokinetics of ustekinumab comparable in Asian patients with psoriasis and in patients with non-Asian psoriasis. The use of alcohol or tobacco did not affect the pharmacokinetics of ustekinumab.

testimony

plaque psoriasis

Adult patients
Treatment of patients over 18 years of age with moderate to severe plaque psoriasis in the absence of the effect of the treatment or in the presence of contraindications or intolerance to other methods for systemic sustanon 250 cycle therapy or phototherapy.

Children
Treatment of children aged 12 to 18 years with moderate to severe plaque psoriasis in the absence of the effect of the treatment or in the presence of contraindications or intolerance to other methods for systemic therapy or phototherapy.

Psoriatic arthritis
Treatment of patients over 18 years of age with active psoriatic arthritis (PsA) as monotherapy or in combination with methotrexate.

Contraindications

– Clinically significant hypersensitivity to ustekinumab or any excipient product;
– Children under the age of 12 years (as indicated by “plaque psoriasis”), up to 18 years (as indicated by “psoriatic arthritis”);
– Pregnancy and lactation;
– Serious infectious disease acute phase, including tuberculosis;
– Malignant neoplasm.

Carefully

– Chronic or recurrent parasitic and infectious diseases of viral, fungal or bacterial origin.
– Malignant tumors in anamnesis.
– Older age.

Use during pregnancy and lactation

Pregnancy
During the study drug was administered to animals in a dose of 45 times the recommended clinical dose for humans, while there was no evidence of teratogenicity effects, birth defects or developmental delays. However, the results from animal studies are not always applicable to humans.
It is unknown whether ustekinumab is when used in pregnant women result in adverse effects on the fetus or affect reproductive function. There are no adequate and well-controlled studies in pregnant women have been conducted.
It is not recommended sustanon 250 cycle to use the drug during pregnancy, effective methods of contraception during and for 15 weeks after treatment with the drug should be used.

Lactation
Studies in monkeys showed that ustekinumab is excreted in breast milk. It is not known whether the drug is absorbed systemically after absorption. Because many drugs and immunoglobulins are excreted in human milk and because the drug Ctelara ® can cause adverse reactions in infants, should decide to breast-feed while taking this drug, or the abolition of ustekinumab therapy.

Dosing and Administration

Preparation Ctelara ® is intended for subcutaneous injection.

Adult patients

Plaque psoriasis
The recommended dose is 45 mg. Making a second injection 4 weeks after the first application, then every 12 weeks. In patients weighing more than 100 kg of the drug is recommended at a dose of 90 mg.
In case of failure of therapy for 28 weeks is recommended to consider the appropriateness of the drug.

Dose adjustment
Patients who have clinical efficacy in the application every 12 weeks expressed enough, increase the dose to 90 mg every 12 weeks. In such case the dosing regimen is not effective, the dose should be administered 90 mg every 8 weeks.

The resumption of treatment
was shown, that the resumption of therapy according to the scheme: a second injection 4 weeks after the first application, and then every 12 weeks, is effective and safe.

Psoriatic arthritis
The recommended dose is 45 mg. Making sustanon 250 cycle a second injection 4 weeks after the first application, then every 12 weeks. In patients weighing more than 100 kg of the drug it is recommended to use a dose of 90 mg. anazole

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